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Alpha GPC, Choline Alfoscerate

 

Choline alfoscerate (also known as Alpha-GPC) is L-a-glyceryl phosphorylcholine (GPC), a key brain cell membrane phospholipid and cholinergic precursor. It is a source of choline for the synthesis of the neurotransmitter acetylcholine, with a greater ability to penetrate the blood-brain barrier than conventional choline sources.

Alpha GPC, Choline Alfoscerate

 

 

 

Product name:  Choline glycerophosphate, Choline Alfoscerate
Other name:    Alpha GPC, L-ALPHA-Glycerophosphoryl choline;
Choline Glycerophosphate; (2S)-2,3-dihydroxypropyl 2-(trimethylammonio)ethyl phosphate; (2R)-2,3-dihydroxypropyl 2-(trimethylammonio)ethyl phosphate.
CAS Number :  28319-77-9
Formula:  C8H20NO6P
Mol. Mass:  257.22                 
Appearance:  off-white to white crystalline powder or colorless sticky liquid.
Specification: 50% &99% powder , 85% liquid
50% granular powder for Tablet & Hard Capsule(patent pending)
Package: 25kg/drum

  

1.What is Alpha GPC ?

Choline alfoscerate (also known as Alpha-GPC) is L-a-glyceryl phosphorylcholine (GPC), a key brain cell membrane phospholipid and cholinergic precursor. It is a source of choline for the synthesis of the neurotransmitter acetylcholine, with a greater ability to penetrate the blood-brain barrier than conventional choline sources. 

 
Choline alfoscerate is an important neurotransmitter and phospholipid precursor providing support for age-related decline in cognitive function, memory, and cerebrovascular health

Choline alfoscerate (Alpha GPC) has been experimentally demonstrated to reduce or reverse age-related structural changes in the frontal cortex and hippocampus and induced functional deficiencies of the cholinergic system. Research supports choline alfoscerate's ability to support healthy brain function and the release of somatotrophin (hGH).  

 

2  How does Alpha GPC work ?

 

Choline from the diet is transported to the brain for use. Extra choline is stored in cell membranes, and alpha-GPC is an intermediate step. The process begins when choline is converted into a substance called CDP-choline, which is then converted into another chemical called PC. This is used as a building block in cell membranes. Later, when there is a shortage of choline, PC is extracted from cell membranes. This PC is broken down into alpha-GPC, which is further broken down into choline.

  

Ingested alpha-GPC enters brain cells easily and waits until it’s needed. Now, when brain cells require more choline, they have a choice between grabbing PC from their membranes or using what’s floating around. The latter option skips a step in the process and preserves the integrity of cell membranes. This, in turn, allows the brain to maintain high cognitive function without self-destructing.

 

3.What are the Benefits of taking Alpha GPC

 

Main functions :

   
GPC has been shown to:

 
• Help brain recovery following injury, coma, and surgery
• Improve memory and cognitive performance in patients with Alzheimer's dementia
• Improve memory and learning ability in laboratory animals
• Counteract brain aging in rats by increasing cholinergic receptor sites, restoring the bioavailability of acetylcholine, increasing nerve growth factor receptors in the brain, and slowing down undesirable structural changes in the brain
• Counter the age-related loss of nerve cells and fibers in the brain
• Protect the brain and other organs against toxic waste buildup
• Support patients recovering from cerebral ischemic attacks
• Increase the release of dopamine, the neurotransmitter that plays a major role in Parkinson's disease

 


Studies have investigated its efficacy for cognitive disorders including stroke and Alzheimer’s Disease. An Italian multicentre clinical trial on 2,044 patients suffering from stroke were supplied alpha-GPC in doses of 1,000 mg/day for 28 days and 400 mg three times per day for the five ensuing months. The trial confirmed the therapeutic role of alpha-GPC on the cognitive recovery of patients based on four measurement scales, three of which reached statistical significance.

  

Other functions  :

 


1. Growth Hormone

 

Research supports choline alfoscerate' s ability to support healthy brain function and the release of somatotrophin (hGH).

Another study has reported that 600mg Alpha-GPC taken 45 minutes prior to physical exercise is able to augment the exercise-induced growth hormone spike from 5.0+/-4.8ng/mL in placebo to 8.4+/-2.1 ng/mL with supplementation. The increase appeared to be significantly more than placebo when measured immediately and up to 15 minutes after exercise cessation, normalizing at 60 minutes


2. Fat loss


One study using Alpha-GPC at 1,000mg has reported that, in otherwise healthy men, an increase in plasma biomarker of lipolysis (the ketone bodies acetoacetate and 3-hydroxyacetate, as well as free fatty acids) was reported to occur 120 minutes after supplement ingestion  

 

3. Power Output

 
Supplemental of Alpha-GPC given 600mg Alpha-GPC prior to a power test (bench throws) reported a 14% power output improvement relative to placebo when taken 45 minutes prior to activity
 

4. Recommended dosage



A standard dosage of alpha-GPC is 300-600 mg, according to the most common label doses. This dose is in accordance with the study using alpha-GPC to enhance power output (600 mg) and the two studies noting an increase in growth hormone secretion, and is likely a good dose to take for athletes.

 

For the usage of alpha-GPC in attenuating symptoms of cognitive decline, almost all studies use a dosage of 1,200 mg daily, divided into three doses of 400 mg. It is unsure how lower doses would benefit cognition, but the 1,200 mg appears to be consistently associated with benefit.

 

 

5. Brief Introduction of Purelife Bio Alpha GPC :

 

Purelife Bioscience is the biggest manufacturer of alpha GPC in China. In the year of 2014, we set up the third branch plant in Korea ,which has been certified by ISO & KGMP,  is specially for the production of L-alpha-Glycerylphosphorylcholine ( Alpha GPC) only.

Current Production capacity per month is 10000—12000kg (the total data includes China and Korea factories).  DMF is available .

 

We guarantee :

100% do not contain any animal ingredients

100% GMO Free

Only Ethanol (Drug grade) used as solvents , no other organic solvents used.

It meets API standard

 

Our Specification of Alpha GPC

Alpha GPC  99% fine powder

Alpha GPC 85% liquid (Pharmaceutical Grade , drink & softgel application)

Alpha GPC 50% Granular powder(tablet & capsule application)

Alpha GPC 50% fine water-soluble powder (drink & powder application)

 

 

Our Key specification of Alpha GPC :  Alpha GPC 50% Granular powder

 

In general, Alpha GPC powder is highly water-absorbable, and easy to damp , which is not good for store as tablet or hard capsules.   

 

 

Our new technology (patent pending) resolves this issue , the new granular powder flows very well, can’t be easily deliquesced . It has improved Alpha GPC’s stability ,  it is special for Alpha GPC tablet & hard capsule production .  

 

 

 

 

 

 

 

 

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Purelife Bioscience Co., Ltd      Room 2201, No 116 Dongjing Road, Pudong New area,Shanghai 201208,P.R.China
Tel : 0086-21-60581189 Fax : 0086-21-60581100    Email : info@purelife-bio.com