Product name:  Caffeic Acid Phenethyl Ester, CAPE

Other name :   Phenethyl Caffeate, 3,4-Dihydroxy-trans-cinnamic acid phenethyl ester

CAS No.:            10594-70-9

Appearance:     Light brown powder.

Purity :              NLT 98%

Caffeic Acid Phenethyl Ester

What is Caffeic Acid Phenethyl Ester

Caffeic acid phenethyl ester (CAPE), which an active component of propolis from honeybee hives, is the ester of caffeic acid and phenethyl alcohol.  It is known to have anti-mitogenic, anti-carcinogenic, anti-inflammatory, and Immunomodulatory properties .

CAPE is a specific inhibitor of the nuclear transcription factor, NF-κB. It has been shown to significantly suppress the Lipoxygenase pathway of arachidonic acid metabolism during inflammation. Also , CAPE inhibits HIV-1 integrase, and inhibits proliferation of transformed cells as well. It induces apoptosis in transformed fibroblasts, and interferes with EGF signal transduction affecting both protein kinase C and Ornithine Decarboxylase activity.

CAPE effective/benefit  :

  • Cytotoxic agent against cancer cell lines.
  • Inhibitor of ornithine decarboxylase and protein tyrosine kinase.
  • Induces apoptosis, modulates redox state of cells
  • Suppresses acute inflammation.