Product name : L-5-Methyltetrahydrofolate Calcium

Synonyms :

Calcium L-5-Methyltetrahydrofolate


L-Methyltetrahydrofolate calcium salt

L-Methylfolate calcium


CAS Number :  151533-22-1

Appearance: White to light yellow crystalline powder



L-5-Methyltetrahydrofolate Calcium

What is L-5-Methyltetrahydrofolate Calcium?

L-5-Methyltetrahydrofolate Calcium is the calcium salt form of L-5-Methyltetrahydrofolate (L-Methylfolate), which is the most bioavailable and active form of folic acid (vitamin B9) the human body can actually use. L- and 6(S)- forms are biologically active, while D- and 6(R)- are not.

How Does L-5-Methyltetrahydrofolate Calcium Work?

The forms of vitamin B9 include folic acid and folate. Folic acid is the supplemental or “synthetic” form of vitamin B9 and is typically the first line of treatment for folate deficiency and related health conditions. While folate is the natural form of vitamin B9, which occurs naturally in some vegetables.

However, no matter folic acid or folate we ingest, both of them must be metabolized into Dihydrofolate (DHF), Tetrahydrofolate (THF), and then finally into L-5-Methyltetrahydrofolate (5-MTHF) to be used in the body. This fact means L-5-Methyltetrahydrofolate (5-MTHF) is useful for human only , but the whole convert process requires the MTHFR enzyme , if our body can’t do this conversion effectively (lack of MTHFR enzyme) , folic acid and folate somewhat useless to us .

L-5-Methyltetrahydrofolate (5-MTHF)is the only one form of folic acid and folate able to cross the blood-brain barrier, it plays a role in DNA synthesis and repair , promotes body’s ability to produce healthy DNA, have healthy neurotransmitter production, and optimal cardiovascular, hormonal, cellular, liver and reproductive functions.


L-5-Methyltetrahydrofolate Calcium Benefits/functions:

  • Beneficial in treating severe depression and diabetic neuropathy
  • For pregnant women and fetal health
  • Supports healthy heart and nerve function
  • Supports healthy cardiovascular support
  • Prevents Alzheimer’s and Parkinson’s disease

L-5-Methyltetrahydrofolate Calcium Recommended dosage

Take 1mg daily or as directed by your healthcare practitioner.

Purelife bio’s good quality on L-5-Methyltetrahydrofolate Calcium :

  • 100% do not contain any animal ingredients
  • 100% GMO Free
  • Crystalline ,not amorphous form ,more stable , higher bioavailability
  • cGMP manufacturer
  • Comply with vegetarian diets standard
  • Meets USP standard