Product name :  Neohesperidin dihydrochalcone

Synonyms :    Neohesperidin DHC, NHDC, Neohesperidin DC

CAS Number :  20702-77-6

Appearance:    White to pale yellow needle crystal powder

MF：C28H36O15

Purity :  98%

Usage :  Sweetener & Flavor ingredient

Neohesperidin dihydrochalcone

  • What is Neohesperidin dihydrochalcone ?

Neohesperidin dihydrochalcone, also known as neohesperidin DC or NHDC, is a type of flavonoid derivative extracted from citrus plants (naringin or hesperidin). As a strong sweetener and flavor enhancer, neohesperidin DC(NHDC) is used in a wide range of products including foods, medicines, dietary supplements, cosmetics and feeds.

  • Neohesperidin dihydrochalcone characteristics and advantages

  • High-Sweetness, Low-Calorie

The sweetness of NHDC is roughly 1500-1800 times sweeter than sugar at threshold concentrations, meanwhile, it is around 20-30 times sweeter than saccharine. Also, NHDC can be used for shielding bitterness because of its long-lasting aftertaste.

NHDC hydrolysis in the body, but its glycosido radical doesn’t take part in the metabolism of human body , so it’s a good sweetener of low calorie food .

  • Long-lasting aftertaste

Neohesperidin DC tastes cleanlily , has long aftertastes .Therefore , NHDC can bind to bitter receptor even below its sweetness threshold, and reduce the bitterness of pharmaceutical drugs in tablet or syrup form. For instance, both viagra contains NHDC as a Bitterness Masking

Neohesperidin dihydrochalcone

  • Good stability and high safety

Neohesperidin DC is non-hygroscopic, nontoxic , non-cariogenic, it is safe without side effect..

Regulatory Status

.GRAS by the Expert Panel of FEMA as a flavor ingredient (#3811);

.EU food additives regulations included (# E959);

.Australian National Food Authority approved as “flavoring substances”;

.”European Pharmacopoeia” (EP-7) included;

.U.S. Pharmacopoeia Commission “Food Chemicals Codex substance” (US-FCC8) included.

.The Chinese Standards of using food additives included GB2760-2011（#S0269）

  • Anti-Oxygenation

Neohesperidin dihydrochalcone (NHDC) has strong anti-oxidation activity (stronger than hesperidin’s). A study shows that NHDC has remarkable effect on scavenging stable free radicals and reactive oxygen species (ROS), it is the most effective inhibitors of hydrogen peroxide and hypochlorite . Also , NHDC can inhibit protein degradation , protect the skin premature aging due to exposure to infrared radiation , so it is an anti-browning agent and skin lightener .

  • Lower cholesterol & blood sugar levels

NHDC inhibits reductase (HMG-COA and ACAT) activity , it significantly reduces the content of plasma cholesterol and neutral lipid in body , and prevents hardening of the arteries and diseases of the blood circulation system . In the meanwhile , NHDC can improve animal plasma high-density lipoprotein(HDI) content , thus promoting cholesterol metabolism .

Also , NHDC inhibits mammalian alpha-amylase , it means NHDC can reduce the absorption of sugar in body , and lower blood sugar level . So it is a very good supplement for diabetics .

  • Prevent Ulcers

As Ranitidine , which is a common drug for reducing gastric acid , NHDC is expected to be a new ingredient of digestant  , because it can inhibit the activity of histamine, and reduce the secretion of gastric acid and pepsin obviously

  • Neohesperidin dihydrochalcone application

Food Flavor

The flavor of NHDC is similar to maltol and ethyl maltol, and it produces significant synergistic effect with other flavor ingredient. Widely used in frozen milk products, candies, puddings, fruit juices, non-alcoholic beverages, condiments, jams, chewing gums and so on.

Bitterness Masking for Pharmaceuticals

Neohesperidin DC tastes cleanlily , has long aftertastes .Therefore , NHDC can bind to bitter receptor even below its sweetness threshold, and reduce the bitterness of pharmaceutical drugs in tablet or syrup form. For instance, viagra contains NHDC as a Bitterness Masking

Sweetener

Neohesperidin DC has strong & pure sweetness , it is widely used in water-base, milk-based, and juice-based beverages, ice-creams, wines, desserts, cakes, bakery products, candies, etc.

Neohesperidin dihydrochalcone

Feeding stuff

Neohesperidin DC improves palatability of feeding stuff , and increases animal appetite , then stimulates their growth

  • Neohesperidin dihydrochalcone recommended dosage

  • For dairy products & desserts , such as spreads, icecreams etc , the dosage :

10-35 ppm ( sweetener) , 1-5 ppm( flavor enhancer)

  • For Pharmaceutical Bitterness Masking , the dosage:

10-30 ppm( sweetener) , 1-5 ppm( flavor enhancer)

The dose is determined by different purposes.

. Comparing with other sweeteners

NHDC has higher sweetness , it is 1500-1800 times sweeter than sugar, while sucralose is 400-800 times and ace-k is 200 times sweeter than sugar . NHDC sweet tastes like licorice. It has a strong synergistic effect when used in conjunction with other artificial sweeteners such as aspartame, saccharin, acesulfame potassium, and cyclamate, as well as sugar alcohols such as xylitol, so the use of NHDC boosts the effects of these sweeteners; smaller amounts of other sweeteners are needed, and reduce the costs.

In addition to be a sweetener , NHDC has the functions on lowering cholesterol & blood sugar levels , which other sweeteners don’t have , so NHDC is the most suitable sweetener for diabetics .

Also , other sweeteners can’t inhibit bitter taste well . NHDC can bind to bitter receptor even below its sweetness threshold, and reduce the bitterness of pharmaceutical drugs in tablet or syrup form. Furthermore, NHDC has the Longest-lasting aftertaste , so it can be used as a wonderful Bitterness Masking in pharmaceutical industry .



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