Urolithin B from Pomegranate
Pomegranate, as known as Punica Granatum , has been used as a fruit or dietary supplement by people for a long time . Pomegranate is believed to be one of the healthiest fruits, why? It has an impressive nutrient profile:
One cup of pomegranate arils (seeds) (174 grams) contains:
Fiber: 7 grams.
Protein: 3 grams.
Vitamin C: 30% of the RDA.
Vitamin K: 36% of the RDA.
Folate: 16% of the RDA.
Potassium: 12% of the RDA.
The seeds is also very sweet, with one cup containing 24 grams of sugar, and 144 calories
Pomegranate is a rich source of some powerful antioxidants, includes : Punicalagins, Punicic Acid, Polyphenol, Ellagic acid , Vitamin C and so on . These active ingredients make Pomegranate extract have numerous benefits for :
. High blood pressure
. Healthy Aging
. Anti- inflammation
. Breast/Prostate cancer
. Brain boosting
. High cholesterol
. Fat loss
Let’s further introduce this amazing herbal extract. Besides above active ingredients that pomegranate extract contains, Urolithins is another interesting compound we found in pomegranate. According to Wikipedia, urolithins are microflora human metabolites of dietary ellagic acid derivatives such as ellagitannins, they are produced in the human gut, and found in the urine in the form of urolithin B glucuronide after absorption of ellagitannins from pomegranate. We just talked that the health benefits attributed to pomegranate have been associated with its high content in powerful antioxidants, particularly ellagitannins, but as per studying, the bioavailability of ellagitannins is very low, our body doesn’t absorb it as is, when ellagitannins arrives in our intestine, certain bacteria of our microbiota transform it into urolithin A, B, C or D, which our blood then absorbs. Therefore, it is conceivable that the health effects of ellagitannin-containing products can be associated with these gut-produced urolithins, and thus the evaluation of the biological effects of these metabolites is essential.
Urolithin B for muscle mass
Urolithin B( CAS NO :1139-83-9) is an urolithin ,it is also produced in the human gut after absorption of ellagitannins from pomegranate.
Urolithin B can mitigate muscle damage experienced during intense exercise and protect muscle against stresses induced by a high-fat diet. Clinical research on Urolithin B in mice found that it enhanced myotubes growth and differentiation by increasing protein synthesis. It demonstrated an ability to inhibit the ubiquitin–proteasome pathway (UPP), the principal mechanism for protein catabolism. It also induced muscle hypertrophy and reduced muscle atrophy.
When compared to testosterone, Urolithin B when taken at 15 uM increased androgen receptor activity by 90% while testosterone was only able to accomplish increased receptor activity of 50% at 100uM. This means that it takes a lot less Urolithin B to increase androgen activity more effectively then the higher amount of testosteronewhich increases androgen activity less effectively.
Moreover, most effective 15uM of Urolithin B larger muscle protein synthesis via 96% when in comparison to 100uM of insulin, which larger muscle protein synthesis via most effective 61%. The belief is that it takes a long way much less Urolithin B to extend muscle protein synthesis with a lot upper degree of effectiveness.
This studies show that Urolithin B can inhibit protein catabolism while simultaneously increase protein synthesis, it is a natural ingredient that helps to build lean muscle while preventing muscle breakdown.