Nicotinamide riboside NR has been tested in various research experiments. The vitamin has shown significant positive results on mice that were fed a high-fat diet. Research shows that mice taking nicotinamide riboside in high doses in combination with their high-fat diets can minimize their risk of getting diabetes while preventing them from gaining weight. In addition, the molecules provided their muscles with more endurance to make them run faster for a longer period of time. The same benefits that were observed in mice have also been reported by people that wanted to provide their honest opinion about the vitamin. Hence, researchers are thinking of conducting other experiments and various tests on humans in order to sort out essential details and show that it can provide amazing health benefits.
Benefits Of Nicotinamide Riboside (NR)
In a Swiss research center, they also found that mice taking nicotinamide riboside had experienced a significant amount of weight loss while being on a high-fat diet. These mice lost much more weight than the group of mice that were fed the same diet without nicotinamide riboside. Researchers also observed that NR gave mice a lot more energy compared to the mice in the placebo group. In addition, mice that were given NR showed lower cholesterol levels than those that were not given NR. All of these benefits came without any adverse side effects.
We show that NR supplementation in mammalian cells and mouse tissues increases NAD(+) levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high-fat diet-induced metabolic abnormalities. Consequently, our results indicate that the natural vitamin NR could be used as a nutritional supplement to ameliorate metabolic and age-related disorders characterized by defective mitochondrial function.
