N-acetylcysteine ethyl ester for COVID-19
What is N-acetylcysteine ethyl ester (NACET)?
Before answering this question, we first need to know what N-Acetyl-L-cysteine (NAC) is. N-Acetyl Cysteine (NAC) has a similar structure to the amino acid L-cysteine, as it is its acetylated form. N-acetyl cysteine shares a similar structure with the enzyme glutathione, being its direct precursor.
As N-Acetyl-L-cysteine (NAC) is a precursor of glutathione, the master antioxidant in your body, which makes NAC has antioxidant properties and many other health benefits on brain, liver, kidney health and so on :
NAC as a nootropic
NAC can cross your blood-brain barrier , increase the glutathione levels in the nerve tissues, and regulate glutamate levels in your brain, it may alleviate symptoms of multiple psychiatric disorders and reduce addictive behavior, and may benefit those with brain and memory ailments. NAC is currently being recommended by physicians and psychiatrists for people with psychiatric problems such as :
- Major depressive disorder
• Bipolar disorder
• Drug addiction
• Obsessive-compulsive disorder
• Autism
• Schizophrenia
• Alzheimer’s disease
• Certain forms of epilepsy (progressive myoclonic)
NAC prevents Liver and Kidney damage
NAC plays an important role in your body’s detoxification process, it can help prevent side effects of drugs and environmental toxins, especially for steroid users, bodybuilders, hepatitis and nephritis patients. Liver/Kidney health is directly correlated with liver/Kidney glutathione content for its main protection against damage. In fact, glutathione is possibly the most important immune and cellular defense against toxins and oxidants.
NAC for Lung health
NAC is able to reduce the thickness of the mucus produced in the lungs of individuals with chronic bronchitis. It is this mucus that causes breathing to be difficult in bronchitis sufferers. N-Acetyl Cysteine’s antioxidant activity has also been shown to offer a protective function within the lung’s cells, thereby reducing bronchitis’ impact. Bronchitis is primarily the result of inflammation of the bronchial tubes within the lungs. This inflammation can be decreased through the antioxidant actions of glutathione, produced by NAC.
Actually , NAC has been heavily researched for its role in optimizing lung health. In the early 1860s, NAC was used as a mucolytic agent for respiratory diseases. For the patients with lung infection with mucous sputum. NAC can not only crack sputum, promote ciliary beating to eliminate phlegm, but also has the functions of anti-oxidation, anti-inflammation, reducing the pathogenicity of airway pathogens and immunity enhancement. Now in China, NAC is one medication that curing/ preventing the COVID-19. At the same time, it is under a clinical trial for COVID-19 curing in the US , should be approved by FDA soon .
N-acetylcysteine ethyl ester for COVID-19
After the introduction of N-Acetyl-L-cysteine (NAC), let’s talk about NACET, what is NACET? Can we use N-acetylcysteine ethyl ester for COVID-19 prevention?
N-Acetyl-L-cysteine ethyl ester powder (NACET), CAS NO : 59587-09-6 , is a NAC derivative. The esterification of the carboxyl group to produce N-acetyl cysteine ethyl ester increases the lipophilicity of NAC and greatly improves its pharmacokinetics. NACET has much higher bioavailability (around 60%) than NAC. NACET rapidly enters the cells, then is trapped, and transforms into NAC and Cysteine. NACET is found in the cells of different tissues, including brain as it is able to cross the blood-brain barrier. NACET also provides a variety of protective antioxidant effects. NACET may be taken orally and helps increase glutathione. It can accumulate in human erythrocytes. NACET may also behave as a potent protector against hydroperoxide induced oxidative damage.
NACET is rapidly absorbed in rats after oral administration but reaches very low concentrations in plasma. This is due to a unique feature of NACET: it rapidly enters the cells where it is trapped being transformed into NAC and cysteine. After oral treatment, NACET (but not NAC) was able to increase significantly the glutathione content of most tissues examined, brain included, and to protect from paracetamol intoxication in the rat.
NACET has also the unique feature to accumulate in human erythrocytes where it behaves as a potent protector against hydroperoxide-induced oxidative damage. Our study shows that being able to enter cells and to produce NAC and cysteine, NACET increases circulating hydrogen sulfide (H(2)S), thus representing a good candidate for the oral use as an H(2)S producer, with clear advantages over NAC. NACET has the potential to substitute NAC as a mucolytic agent, as a paracetamol antidote and as a GSH-related antioxidant. Therefore, NACET has the same effects as NAC, and NACET is much better than NAC , because of NACET much higher bioavailability .
N-acetylcysteine ethyl ester (NACET) dose
No enough scientific information to determine the exact dose yet, it depends on user’s age, health, material content and other conditions. But 500mg—1000g daily is ok, please consult your dietitian for an appropriate dose before you supplement.
Where to buy N-acetylcysteine ethyl ester (NACET)
Purelife bio is a professional and reliable supplier of raw material of N-acetylcysteine ethyl ester (NACET) with top quality. If you need certificate of analysis of NACET, MSDS, pricing quotation, test spectrum or have any other technical questions, please kindly drop us an email, a timely and professional support will be provided upon your request.
