TUDCA Supplement

Product name: Tauroursodeoxycholic acid (TUDCA)

Synonyms:    TUDCA, TUDCA Supplement

Tauroursodeoxycholate

2-(3α, 7β-Dihydroxy-5β-cholan-24-oylamino)etanesulfonic acid

Appearance:  Off-White to white powder

CAS NO:      14605-22-2

MF：C26H45NO6S

MW：499.70

Assay:  ≥98.0% by HPLC

TUDCA supplement

Tauroursodeoxycholic acid (TUDCA) review /What is Tauroursodeoxycholic acid (TUDCA) ?

Tauroursodeoxycholic acid (TUDCA) is an ambiphilic bile acid. TUDCA is formed in the liver by conjugation of deoxycholate with taurine. It is a taurine conjugate derived from ursoodeoxycholic acid. Humans are found to have trace amounts of TUDCA, but a much higher content of TUDCA can be found in animals bile, such as bear, chicken etc .While, bile helps with our digestion, assisting the body in breaking down fats into fatty acids making them easier for our digestive tract to take in. Bile is made up of 4 main components; Cholesterol, Bilirubin, Bile Acids (also called Bile Salts) and water. So why TUDCA supplement is more and more popular in nutrition market?

As a bile acid, TUDCA acts as a physiological detergent which means it facilitates absorption, excretion and transportation of fats and sterolds within the liver and intestine. These unique properties make TUDCA ideal for digestion and absorption of nutrients and also for detoxification.

How does Tauroursodeoxycholic acid (TUDCA) work?

TUDCA is a water-soluble bile salt, which is in contrast to regular bile salts possessing both water soluble and fat soluble ends and conferring a detergent effect. This is good for the bile salt’s biological purpose (emulsifying fats in the intestines to help with absorption) but when bile acids back up in the liver, a clinical state called cholestasis which occurs when the liver is unhealthy, these bile salts can be damaging to cells by destroying the membranes and signalling for cell death. TUDCA and other water soluble bile salts like UDCA compete with this toxicity and thus indirectly protect cells from death.

Tauroursodeoxycholic acid (TUDCA) benefits/functions:

 

  • Liver health

A buildup of too many lipophilic bile acids in the liver such as Chenodeoxycholic acid or deoxycholic acid can cause toxic effects like cell death, leading to cholestasis. Since TUDCA is amphipathic, it is able to antagonistically compete with these harmful bile acids in the liver, displacing them from the liver, lowering their concentration and harmful effects.  TUDCA supplement was shown to reduce the effects of apoptosis on the liver, function as a treatment of cirrhosis and promote the overall production of bile acid in the liver.

For bodybuilders, they need to take prohormone, steroid and SARMs in “bulking cycles” to cut fat fast and accelerate muscle growth, which lead to ALT and AST liver enzyme levels increase a lot.

Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) are two crucial enzymes present in the liver. Health professionals commonly measure theses enzyme because they can become elevated in the face of liver damage. The ratio between the two can also help differentiate between the various causes. High levels of ALT and AST can be indicative of hepatitis or primary biliary cirrhosis (PBC), an autoimmune disease that damages bile ducts.

TUDCA consumption has been shown to be highly effective at decrease enzyme levels. A study from the University of Milan saw a 51 percent drop in the level of liver enzymes in women with PBC from two months of TUDCA supplementation.

Also, TUDCA blocks the hepatitis B and hepatitis D viruses from invading liver cells. In fact, of all bile salts, TUDCA is the most effective preventing hepatitis B infection. A 1998 study found TDUCA to be more effective at decreasing aminotransferase serum levels than placebo with progressive improvement of hepatitis.

TUDCA Supplement for liver health

  • Diabetes and Insulin Sensitivity

Insulin is necessary for blood glucose obtained from food to enter cells but sometimes, often genetically, cells become immune to its signals. When this happens cells fail to absorb sufficient glucose from the blood, leading to a state of high blood sugar called hyperglycemia. This condition is responsible for 90 to 95 percent of diabetes cases and strongly associated with abdominal obesity.

TUDCA combats this condition by increasing the glucose-induced release of insulin via the cAMP/PKA pathway. This allows for the enhanced insulin sensitivity in the liver, muscle, and adipose tissue as well as normalization of glucose levels (homeostasis), as supported by studies on both cell cultures and diabetic mice.

 

Studies have demonstrated that Endoplasmic Reticulum (ER) stress contributes to insulin resistance. In one study, 20 subjects were given 1750mg TUDCA/day for 4 weeks. By the end of the study, liver and muscle insulin sensitivity had increased by 30%. Muscle insulin signaling was also increased in the group given TUDCA compared to the control group.

  • Eye health. 

TUDCA was examined for conceivable use in retinitis pigmentosa , a degenerative visual issue.

  • Decreasing cholesterol

TUDCA supplement is a cholesterol fighter given its ability to break down fats and protects nerves in the liver from death by infection. A study from the Institute of Internal Medicine in Italy found a significant decrease in cholesterol in its high dosage group given 1,500 mg of TUDCA daily over a six month period.

 

Tauroursodeoxycholic acid (TUDCA) Recommended dosage

 

Due to limited clinical research, there is no standardized dosage for TUDCA supplement, however, research suggests that anywhere between 250 and 1500 mg per day may be effective.

Most bodybuilders take a dosage between 500 and 1000mg a day if they are on a heavy oral cycle like prohormone, steroid. Some people take higher dosages of 1000mg+ to repair damaged liver after a cycle.

But please do not take TUDCA longer than 8 weeks because it could increase your negative cholesterol and decrease HDL. The FDA also advised not to take tauroursodeoxycholic acid if you do not have signs of damaged liver or gallstones.

TUDCA Supplement Market

As a liver protection supplement, TUDCA is more and more popular now. We can find a wide variety of options online. Some formulas only contain single TUDCA with 250mg per capsule, or pure TUDCA powder. But most formulas contain a bunch of other ingredients, the most common ingredients that contains in TUDCA formulas include N-Acetyl Cysteine(NAC), Milk Thistle extract , Dihydromyricetin(DHM) . So which formula is the most appropriate for you, and what dose should you take daily , please consult your healthcare practitioner .

Where to buy TUDCA raw powder

Purelife bio is a professional and reliable supplier of raw material of TUDCA with NLT 98% purity by HPLC. If you need certificate of analysis of TUDCA, MSDS, pricing quotation, test spectrum or have any other technical questions, please kindly drop us an email at info@purelife-bio.com, a timely and professional support will be provided upon your request.

And raw TUDCA powder is available in our USA warehouse as well.