Skullcap Extract Baicalein Supplement

Product name: Skullcap Extract Baicalein

Other name: 5,6,7-Trihydroxyflavone

Plant Source: Scutellaria baicalensis Georgi, Huang Qin

Part used: Root

CAS number: 491-67-8

Appearance: Yellow to White fine powder

MF： C15H10O5

MW： 270.24

Specification: 50%, 95% & 98% Baicalein (by HPLC)

Skullcap Extract Baicalein Supplement

What is Skullcap Extract Baicalein ?

Baicalein (CAS NO 491-67-8) is a flavone, a type of polyphenolic flavonoid, that is extracted from the roots of Scutellaria baicalensis and Scutellaria lateriflora that have a wide variety of health benefits.

What is Skullcap Extract Baicalein supplement benefits ?

. Baicalein for brain health

In a mice study, scientists discovered that baicalein may help protect against memory impairment induced by amyloid beta, a substance that forms the brain plaques associated with Alzheimer’s disease.

Treatment with this flavonoid in animals, post-stroke, promoted neuron development in damaged sections of the brain, including the new formation of cells in the hippocampus

Another study suggested that the therapeutic efficacy of baicalein on repairing brain damage is probably caused by suppressing apoptosis, oxidative stress and neuroinflammation. Baicalein could be developed into a novel drug for clinical treatment of ICH and ICH-related brain injuries.

Baicalein is a valuable natural compound that can be used to treat brain disorders related to glutamate excitotoxicity. Taiwan researchers found baicalein inhibits depolarization-induced glutamate release in the rat hippocampal nerve terminals (synaptosomes). This study is the first to demonstrate the ability of baicalein to inhibit glutamate release from hippocampal nerve terminals and protect against kainic acid-induced excitotoxicity in vivo.

.Baicalein Reduces Inflammation

Studies indicate baicalein has an anti-inflammatory effect on joints, and supplementation can help relieve arthritic joints, such as the hips and knees (gonarthrosis). It is an excellent substitute for conventional pain-relieving drugs, which are known to have significant and cumulative side-effects.

Baicalein supplements can also help reduce inflammation in bronchial complaints, as well as allergies that affect the sinuses, which promotes easier deeper breathing.

.Baicalein for Anti-diabetic

A Chinese study indicates that baicalein and baicalin, two of the bioactive components in Scutellaria baicalensis, may be useful in treating diabetes. In a laboratory study, researchers treated pancreatic cells from hamsters with each of the skullcap phytochemicals. They found that both substances prolonged the survival rate of these cells and also stimulated their secretion of insulin in the presence of glucose. Researchers published their findings in a 2012 issue of “Advanced Materials Research.”

.Baicalein for Cardiovascular health

Baicalein is a potent free radical scavenger and xanthine oxidase inhibitor, thus improving endothelial function and conferring cardiovascular protective actions against oxidative stress-induced cell injury. Baicalein lowers blood pressure in renindependent hypertension and the in vivo hypotensive effect may be partly attributed to its inhibition of lipoxygenase, resulting in reduced biosynthesis and release of arachidonic acid-derived vasoconstrictor products. On the other hand, baicalein enhances vasoconstricting sensitivity to receptor-dependent agonists such as noradrenaline, phenylephrine, serotonin, U46619 and vasopressin in isolated rat arteries. The in vitro effect is likely caused by inhibition of an endothelial nitric oxide-dependent mechanism. The anti-thrombotic, anti-proliferative and anti-mitogenic effects of the roots of S. baicalensis and baicalein are also reported. Baicalein inhibits thrombin-induced production of plasminogen activator inhibitor-1, and interleukin-1ß- and tumor necrosis factor-α-induced adhesion molecule expression in cultured human umbilical vein endothelial cells. The pharmacological findings have highlighted the therapeutic potentials of using plant-derived baicalein and its analogs for the treatment of arteriosclerosis and hypertension.

.Baicalein for anti-aging

Aging is one of the most complicated phenomena and is the main risk factor for age-related diseases. A study was found that baicalein at concentrations of 0.04, 0.2, and 1 mg/mL extended the mean, median, and maximum life spans in Drosophila melanogaster. Particularly, 0.2 mg/mL baicalein extends the mean and median life spans in male flies by 19.80% and 25.64%, respectively. Meanwhile, it was discovered that baicalein improved fertility in flies. Baicalein exerts antiaging effects likely through attenuating oxidative stress, including increases of CAT activity and GSH level and decrease of GSSG level.

Baicalein or Baicalin , which one is better ?

baicalin or baicalein supplement

Skullcap is an herb commonly used in traditional Chinese medicine, it is rich in flavones, and baicalin and baicalein are two main compounds that skullcap contains. We can find now many nutrition formulas contain baicalin or baicalein supplements, but which one is better? As a matter of fact, Baicalein is stronger. Baicalein is the product of the hydrolysis of Baicalin, Baicalin needs to be converted into Baicalein by enzymes and then absorbed in the human body, and baicalein dosage is much less than baicalin .