Product name: Alpha GPC, Choline glycerophosphate
Other name: Choline Alfoscerate, L-Alpha-Glycerophosphoryl choline, Choline Glycerophosphate
CAS NO : 28319-77-9
Mol. Mass: 257.22
Appearance: Off-white to white crystalline powder or colorless sticky liquid.
Specification: 50% &99% powder, 85% liquid
Package: 25kg/drum , 20kg/carton .
What is Alpha GPC ?
Choline alfoscerate (also known as Alpha-GPC) is L-a-glyceryl phosphorylcholine (GPC), a key brain cell membrane phospholipid and cholinergic precursor. It is a source of choline for the synthesis of the neurotransmitter acetylcholine, with a greater ability to penetrate the blood-brain barrier than conventional choline sources.
Choline alfoscerate is an important neurotransmitter and phospholipid precursor providing support for age-related decline in cognitive function, memory, and cerebrovascular health
How Does Alpha GPC Work ?
Choline from the diet is transported to the brain for use. Extra choline is stored in cell membranes, and alpha-GPC is an intermediate step. The process begins when choline is converted into a substance called CDP-choline, which is then converted into another chemical called PC. This is used as a building block in cell membranes. Later, when there is a shortage of choline, PC is extracted from cell membranes. This PC is broken down into alpha-GPC, which is further broken down into choline.
Ingested alpha-GPC enters brain cells easily and waits until it’s needed. Now, when brain cells require more choline, they have a choice between grabbing PC from their membranes or using what’s floating around. The latter option skips a step in the process and preserves the integrity of cell membranes. This, in turn, allows the brain to maintain high cognitive function without self-destructing.
What are the Benefits of taking Alpha GPC
Main functions :
Alpha GPC has been shown to:
- Help brain recovery following injury, coma, and surgery
- Improve memory and cognitive performance in patients with Alzheimer’s dementia
- Improve memory and learning ability in laboratory animals
- Counteract brain aging in rats by increasing cholinergic receptor sites, restoring the bioavailability of acetylcholine, increasing nerve growth factor receptors in the brain, and slowing down undesirable structural changes in the brain
- Counter the age-related loss of nerve cells and fibers in the brain
- Protect the brain and other organs against toxic waste buildup
- Support patients recovering from cerebral ischemic attacks
- Increase the release of dopamine, the neurotransmitter that plays a major role in Parkinson’s disease
Studies have investigated its efficacy for cognitive disorders including stroke and Alzheimer’s Disease. An Italian multicentre clinical trial on 2,044 patients suffering from stroke were supplied alpha-GPC in doses of 1,000 mg/day for 28 days and 400 mg three times per day for the five ensuing months. The trial confirmed the therapeutic role of alpha-GPC on the cognitive recovery of patients based on four measurement scales, three of which reached statistical significance.
Other functions :
Research supports choline alfoscerate’ s ability to support healthy brain function and the release of somatotrophin (hGH).
Another study has reported that 600mg Alpha-GPC taken 45 minutes prior to physical exercise is able to augment the exercise-induced growth hormone spike from 5.0+/-4.8ng/mL in placebo to 8.4+/-2.1 ng/mL with supplementation. The increase appeared to be significantly more than placebo when measured immediately and up to 15 minutes after exercise cessation, normalizing at 60 minutes
One study using Alpha-GPC at 1,000mg has reported that, in otherwise healthy men, an increase in plasma biomarker of lipolysis (the ketone bodies acetoacetate and 3-hydroxyacetate, as well as free fatty acids) was reported to occur 120 minutes after supplement ingestion
3. Power Output
Supplemental of Alpha-GPC given 600mg Alpha-GPC prior to a power test (bench throws) reported a 14% power output improvement relative to placebo when taken 45 minutes prior to activity
Comparisons with other choline sources
When controlling for the amount of Choline in each supplement, Alpha-GPC requires 46% the dose of CDP-choline and due to being relatively higher in choline on a weight basis, administration of the same doses of either agent result in the group given Alpha-GPC experiencing a greater serum increase in choline. Alpha-GPC is considered to be a more effective (assessed by potency on a weight basis) cholinergic than both choline and CDP-choline when looking at serum values or benefit from clinical interventions.
Small amounts of alpha GPC can be obtained through food however GPC supplements are bio-synthetically created. It is usually created from highly purified lecithin. Lecithin is a common product used for phosphatidylcholine supplementation (a weaker precursor to acetylcholine). Alpha GPC differs from lecithin and carries a different chemical structure. This explains its unique effects and properties over choline and phosphatidylcholine.
Alpha-GPC appears to be the best currently known cholinergic in increasing plasma and brain choline levels, as it has better transportation into the brain than does choline (somewhat similar to CDP-choline) but since it is a greater percentage choline by weight (relative to CDP-choline) taking X dose of either drug gives more choline when using Alpha-GPC
A standard dosage of alpha-GPC is 300-600 mg, according to the most common label doses. This dose is in accordance with the study using alpha-GPC to enhance power output (600 mg) and the two studies noting an increase in growth hormone secretion, and is likely a good dose to take for athletes.
For the usage of alpha-GPC in attenuating symptoms of cognitive decline, almost all studies use a dosage of 1,200 mg daily, divided into three doses of 400 mg. It is unsure how lower doses would benefit cognition, but the 1,200 mg appears to be consistently associated with benefit.
Acute toxicity test LD50 10,000mg/kg
26-weeks repeated toxicity NOAEL > 100mg/day
300mg/day No toxicity
1200mg/day No toxicity
Brief Introduction of Purelife Bio Alpha GPC :
Purelife Bioscience is the most reliable manufacturer of alpha GPC in China. In the year of 2014, we set up the third branch plant in Korea , which has been certified by ISO & KGMP, is specially for the production of L-alpha-Glycerylphosphorylcholine ( Alpha GPC) only.
Current Production capacity per month is 10000—12000kg (the total data includes China and Korea factories). We can guarantee a stable and continuous supply to customers all over the world.
- 100% does not contain any animal ingredients
- 100% GMO Free
- 100% Pesticide Free
- Genotoxic Substances Free
- Comply with vegetarian diets standard
- Only Ethanol (Drug grade) used as solvents, no other organic solvents used.
- Meets API standard
- Available in US warehouse
Purelife bio specifications of Alpha GPC include :
- Alpha GPC 99% fine powder
- AlphaGrain™-GPC( 50% granular & & Non-Hygroscopic powder, for capsule & tablet application)
- Alpha GPC 50% fine powder (water soluble, for drink & powder application)
- Alpha GPC 85% liquid (pharmaceutical grade)
- Alpha GPC 99% powder/85% liquid softgel
- AlphaGrain™-GPC hard capsule