Product name : HMB Ca


Synonyms : Beta-hydroxy beta-methylbutyrate Calcium

HMB Calcium

Calcium β-hydroxy β-methylbutyrate

Calcium 3-Hydroxy-3-methylbutyrate

CAS NO:  135236-72-5

HMB Ca review /What is HMB Ca?


HMB, as knows as β-hydroxy β-methylbutyrate, is a compound that is produced when the body breaks down leucine. Also, HMB mediates a variety of leucine’s effects, dietary intake of leucine can increase HMB formation, and approximately 5% of dietary leucine is converted into HMB in the body

HMB has been shown in scientific studies to protect and repair muscle tissue. It is thought to do this by slowing muscle protein breakdown and speeding protein synthesis, and also by preserving the structural integrity of muscle cells.

How does HMB Ca work ?

HMB increases protein synthesis rates, reduces the breakdown of muscle tissue. It is also a vital structural component used to maintain the integrity of muscle cell membranes, preventing them from damage and supporting rebuild.



HMB or HMB Ca , which one is better ?


HMB can be supplemented in the form of a monohydrated calcium salt (HMB- calcium) or as a free acid(HMB-FA), which is HMB without the calcium salt. The calcium salt has a similar dissociation constant as calcium acetate and has a Tmax in the range of 1-2 hours following ingestion of 1g Ca-HMB, peaking at 487.9+/-19.0nmol/mL (Cmax) with a half-life of 2.5 hours and returning to baseline 9 hours after ingestion, although some HMB may be retained in the body (just not detected in serum; this study noted only 27% was detectable in urine). A later study using 1g calcium HMB noted a Cmax of 131+/-10µmol/L and a return to baseline after 12 hours; the reason for the discrepancy with the same dose is not known.


When comparing the free acid versus the calcium salt (equivalent levels of HMB, so 0.8g free acid versus 1g calcium HMB), the Cmax is higher with the free acid by 76-97% and the Tmax shorter (30 minutes) while the AUC is also increased by 91-97%. When holding the free acid dose sublingually for 15s before swallowing, there do not appear to be any significant differences relative to simply swallowing.

The free acid form appears to be better absorbed and reaches a serum peak level quicker than the HMB-Calcium . But the calcium salt form of HMB can keep it stable as a powder and more soluble in water , also , calcium salt is much cheaper .



HMB Ca benefits/functions :

  • HMB increases protein synthesis rates, helps bodybuilders and atheletes gain muscle faster
  • Reduces Muscle Loss. HMB improves conditions characterized by muscle wasting such as cancer and AIDS, and to promote wound healing following surgery or injury
  • Increases Strength
  • Improves Power Output
  • Improves endurance

HMB Ca Recommended dosage

It should be 1-3g daily. But as always, check with your healthcare practitioner before supplementing.

If you want more detailed info , please free to contact Purelife Bio